When you’re dealing with a runny nose from a cold or relentless allergies, the last thing you want is for your relief to cause more irritation. Standard tissues can quickly leave your nose feeling raw, red, and sore. That’s where facial tissues with lotion come in, offering a much gentler alternative for sensitive skin.
These specialized tissues are infused with soothing ingredients like aloe, coconut oil, and other moisturizers. They provide the strength you need while creating a protective, soft barrier between the tissue and your skin. This roundup will help you find the perfect lotion-infused tissue to keep you comfortable during every sniffle and sneeze.
Our Top Picks for Soothing Lotion Tissues
- Kleenex Ultra Soft Facial Tissues, 3 Flat Boxes
- Kleenex Ultra Soft Facial Tissues, 4 Cube Boxes
- Puffs Ultra Soft Non-Lotion Facial Tissue, 8 Family Boxes
- Amazon Basics Facial Tissue with Lotion, 2-Ply, 1350 Count
- Puffs Plus Lotion Facial Tissues, 4 Family Boxes
- Kleenex Trusted Care Facial Tissues, 3 Flat Boxes
- Kleenex Trusted Care Facial Tissues, 8 Flat Boxes
- Kleenex Lotion Facial Tissues with Coconut Oil, 3 Flat Boxes
- Kleenex Lotion Facial Tissues with Coconut Oil, 8 Cube Boxes
- Puffs Plus Lotion Facial Tissues
Kleenex Ultra Soft Facial Tissues, 3 Flat Boxes

This set of three flat boxes from Kleenex provides a reliable supply of softness for your home. With 120 tissues per box, you get a total of 360 3-ply tissues designed for daily use. They are made to be gentle on skin, offering comfort during allergy season, colds, or any everyday moment that requires a tissue.
The 3-ply construction delivers a combination of silky softness and dependable strength. This means the tissue feels gentle against your nose but is less likely to fall apart during use. The flat box design is perfect for placing on a nightstand, desk, or any room where you need easy access to a soft tissue.
Kleenex Ultra Soft Facial Tissues, 4 Cube Boxes

For those who prefer a cube box design that fits easily on shelves or in bathrooms, this four-pack is an excellent option. It includes four cube boxes, each containing 60 of the 3-ply Ultra Soft tissues, for a total of 240 tissues. The compact shape offers great flexibility for storage around your home.
Just like the flat box version, these tissues are engineered with three layers for a soft and strong performance. The cube format is particularly useful for smaller spaces or for keeping tissues within reach in multiple rooms without taking up much counter space.
Puffs Ultra Soft Non-Lotion Facial Tissue, 8 Family Boxes

This bulk pack from Puffs is ideal for large families or for stocking up. You receive eight family-sized boxes, each with 124 tissues. While this particular variety is non-lotion, it is specifically designed to be gentle on sensitive skin, making it a strong contender for everyday softness.
The large number of boxes means you can place them throughout the house and have a long-lasting supply. Puffs are well-known for their soft texture, and this multi-pack ensures that a gentle tissue is always within arm’s reach when you need it.
Amazon Basics Facial Tissue with Lotion, 2-Ply, 1350 Count

For the ultimate in value and volume, the Amazon Basics option is hard to beat. This pack contains 18 cube boxes with a massive 1,350 tissues in total. These are 2-ply tissues that are infused with lotion, providing a soothing experience with every use.
The lotion infusion is the key feature here, offering extra comfort to help prevent irritation from frequent use. The cube boxes are convenient for distributing around your home or office, ensuring you are well-stocked for the long term.
Puffs Plus Lotion Facial Tissues, 4 Family Boxes

Puffs Plus Lotion is a go-to choice for many seeking relief from nose irritation. This pack includes four family boxes, each containing 124 lotion-infused tissues. The lotion is designed to provide a protective cushion on your skin, which can be especially comforting during a bad cold or allergy attack.
These tissues are known for their combination of strength and soothing care. Having four boxes on hand means you can keep one in the living room, bedrooms, and bathroom, ensuring comfort is always available wherever you are in the house.
Kleenex Trusted Care Facial Tissues, 3 Flat Boxes

The Kleenex Trusted Care line offers the classic softness and strength the brand is known for. This package includes three flat boxes, with 160 2-ply tissues per box for a total of 480 tissues. It’s a practical and reliable choice for general household use.
A notable feature of these tissues is the Clean Shield technology, which is designed to contain messes more effectively. This helps make them a dependable option for blowing your nose, offering both comfort and confidence during use.
Kleenex Trusted Care Facial Tissues, 8 Flat Boxes

This is a larger bulk pack of the trusted Kleenex Trusted Care tissues. With eight flat boxes containing 200 tissues each, you receive a substantial total of 1,600 tissues. This is an ideal solution for offices, large families, or anyone looking to minimize shopping trips.
You get the same dependable 2-ply softness and the benefit of the mess-containing Clean Shield technology in a cost-effective, large-quantity package. It ensures a long-lasting supply of a household essential.
Kleenex Lotion Facial Tissues with Coconut Oil, 3 Flat Boxes

These Kleenex tissues are specifically formulated with coconut oil and aloe to provide superior care for irritated skin. The pack includes three flat boxes, each with 120 3-ply tissues. They are designed to offer three key benefits: soothing, moisturizing, and protecting your hands and nose.
This makes them an excellent choice for sick days, when skin is most vulnerable to redness and soreness. The infusion of coconut oil and aloe helps to moisturize the skin with each use, providing a more comfortable experience during a cold or flu.
Kleenex Lotion Facial Tissues with Coconut Oil, 8 Cube Boxes

This is the cube box version of the nourishing Kleenex lotion tissues with coconut oil and aloe. The pack contains eight cube boxes with 80 tissues in each, totaling 640 tissues. The cube design is space-efficient, making it easy to place in bathrooms, on kitchen counters, or in bedrooms.
You get the same skin-loving formula that soothes and moisturizes to help prevent irritation. The multi-box pack is perfect for ensuring you have these extra-gentle tissues available in every room of your home when you need them most.
Puffs Plus Lotion Facial Tissues
Puffs Plus Lotion is a renowned product line dedicated to providing comfort for sore noses. These tissues are consistently praised for their effective lotion infusion that creates a soft, protective layer on the skin. They are a top choice for anyone who experiences frequent nose irritation from colds or allergies.
The brand has built a strong reputation for delivering a reliable and soothing experience. For those who know and prefer the specific comfort of Puffs Plus Lotion, exploring the various pack sizes and options available can help you find the right quantity for your needs.
Buying Guide: What to Look For in the Best Facial Tissues with Lotion
When my nose is raw from a bad cold or my skin is just feeling extra sensitive, I reach for facial tissues with lotion. But not all of them are created equal. Over the years, I’ve learned that a few key factors make the difference between a tissue that helps and one that just feels greasy. Here’s what I look for when I’m picking out the best facial tissues with lotion for my needs.
First and foremost, I check the ingredient list for the lotion itself. I want something that’s genuinely soothing. Aloe vera and vitamin E are my personal favorites because they are known for their calming and moisturizing properties. I try to avoid tissues with heavy fragrances or alcohol, as these can sometimes irritate skin further, especially when it’s already chapped and sensitive. The goal is to add moisture, not potential allergens.
The strength and softness of the tissue base are just as important as the lotion. A weak tissue that falls apart mid-use is frustrating and messy. I look for a multi-ply tissue that feels sturdy in my hands. At the same time, it needs to be soft. The whole point is comfort, so a sandpaper-like texture defeats the purpose. The best ones I’ve used have a quilted or textured feel that adds to the gentleness on my skin.
I also pay close attention to how the lotion feels. Is it a thick, heavy coating that leaves a noticeable residue on my hands and face? Or is it a light, fast-absorbing layer that moisturizes without feeling sticky? I prefer the latter. A tissue that leaves my skin feeling slick can be uncomfortable, especially if I need to apply makeup or go about my day. The lotion should be present enough to protect, but not so much that it feels like I’ve applied a separate cream.
Finally, I think about value and packaging. While I’m willing to pay a bit more for quality, I want a box that offers a good number of tissues. A flimsy box that collapses or a pop-up mechanism that fails is annoying. A sturdy, well-designed box that dispenses one tissue at a time helps reduce waste and keeps the tissues clean. By considering these factors—soothing ingredients, strength, softness, lotion texture, and packaging—I can find a product that offers real relief. Finding the right facial tissues with lotion can turn a miserable, sniffly experience into a slightly more comfortable one.
Frequently Asked Questions
Are facial tissues with lotion safe for people with very sensitive skin?
This is a great question, and one I had to figure out for myself. While the lotion is meant to be soothing, some formulas contain fragrances or preservatives that can cause reactions. If you have sensitive skin, I recommend looking for hypoallergenic and fragrance-free options. Many brands specifically market their products as being dermatologist-tested for sensitive skin. It might take a bit of trial and error, but starting with a small box of a hypoallergenic brand is a good way to test your skin’s tolerance.
Can I use these tissues to remove makeup?
You technically can, and I’ve done it in a pinch, but I wouldn’t recommend it as a primary makeup remover. The lotion in the tissues can help break down makeup, but they aren’t designed for thorough cleansing. They might not effectively remove all makeup, especially waterproof formulas, and could potentially smear it around or clog pores if not followed by a proper wash. I find them best for final touches or when I need to quickly fix a smudge, not for a full face of makeup.
Why do these tissues sometimes feel less absorbent than regular ones?
I’ve noticed this too! The lotion coating can create a slight barrier that slows down the absorption of moisture compared to a plain, dry tissue. This isn’t necessarily a bad thing; it’s part of what creates that protective layer between your skin and the moisture. The trade-off for the added comfort and protection is a slight decrease in instant absorbency. For very runny noses, you might find yourself using a tissue for a shorter time before grabbing a new one.
Do they clog pipes or septic systems more than regular tissues?
This is an important practical concern. While most major brands of facial tissues are designed to break down relatively quickly in water, the added lotion could theoretically have a slight effect. However, they are generally considered safe for standard plumbing and septic systems when flushed in normal amounts, just like regular toilet paper. That said, if you have an older or sensitive plumbing system, it’s always a good practice to dispose of them in a trash can to be safe. I always check the packaging for any specific “flushable” claims or warnings.
Are there eco-friendly options for facial tissues with lotion?
Yes, the market is slowly growing here! While traditional lotion tissues aren’t always the most eco-friendly due to the processing and additives, you can find better options. Look for brands that use recycled paper for the tissue base and source their materials sustainably. Some companies are also focusing on plant-based lotion ingredients and minimal, recyclable packaging. It requires a bit more research, but more environmentally conscious choices for gentle nose care are becoming available.